cns disorders — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7626	Budipine		Others
	Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist,is an antiparkinsonian agent.		Others
T16849	SB-222200		Neurokinin receptor
	SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM).		Neurokinin receptor
T5411	PDE10-IN-1	SEP-0372814	PDE
	PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.		PDE
T12139	N-(3-Methoxybenzyl)Palmitamide		FAAH
	N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders.		FAAH
TN1048	Cnidilin	Knidilin
	Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
T10170	5-HT7 agonist 1	4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole	5-HT Receptor
	5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM). 5-HT7 agonist 1 can be used in studies about CNS disorders.		5-HT Receptor
T77597	SXC 2023	(S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid	Others
	SXC 2023 ((S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid) is a therapeutic prodrug of N-acetyl-L-cysteine for the treatment of CNS disorders and neurocognitive disorders, and can be used to treat glutamatergic dys...		Others
T3S2105	N-Benzylpalmitamide	Macamide 1,N-Benzylhexadecanamide	Others , FAAH , Autophagy
	N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders...		Others , FAAH , Autophagy
TP2309	NEUROTENSIN TFA (39379-15-2 free base)	Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA	Others
	Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a...		Others
T31264	Deanol acetamidobenzoate	Deanol p-acetamidobenzoate,Elevan,Diforene,Cervoxan,Deaner
	Deanol acetamidobenzoate is CNS stimulant. It can be caused elevated blood choline levels, can be used in Treatment of Choreiform Movement Disorders.
T39673	Zagociguat
	Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-centr...
T61375	5-HT7 agonist 2
	5-HT7 agonist 2 is a highly potent 5-HT7 receptor agonist, exhibiting an IC50 value of 28.7 nM. This compound holds promise for studying and understanding various Central Nervous System (CNS) disorders [1].
T61210	R-PSOP
	R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous syste...
T71593	AVN-101 free base
	AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
T62946	Dopamine D3 receptor antagonist-2
	Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.
T79804	5-HT2 agonist-1		5-HT Receptor
	Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. The free base form of this compound is utilized in research pertaini...		5-HT Receptor
T38222	N-(α-Linolenoyl) Tyrosine
	Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) ...
T35930	Ganglioside GM2 Mixture (sodium salt)
	Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse mo...
T73359	NYX-2925
	NYX-2925, an orally active NMDAR (N-methyl-D-aspartate receptor) modulator, enhances activated Src levels and Src phosphorylation at GluN2A and GluN2B sites in the mPFC (medial prefrontal cortex), without affecting CAMKI...